irremediable (adj.)
- bankrupt
- blasted
- blighted
- broken
- destroyed
- down-and-out
- fallen
- finished
- gone
- impossible
- incorrigible
- incurable
- inoperable
- irreclaimable
- irrecoverable
- irredeemable
- irreparable
- irretrievable
- irreversible
- irrevocable
- kaput
- lost
- ravaged
- ruined
- ruinous
- spoiled
- terminal
- uncorrectable
- undone
- unmitigable
- wasted
- wrecked