irreversible (adj.)
- changeless
- chronic
- confirmed
- constant
- deep-rooted
- deep-seated
- deep-set
- direct
- established
- fast
- final
- fixed
- gone
- immediate
- immutable
- implanted
- incommutable
- inconvertible
- incorrigible
- incurable
- indefeasible
- inert
- ingrained
- inoperable
- invariable
- inveterate
- irreclaimable
- irrecoverable
- irredeemable
- irremediable
- irreparable
- irretrievable
- irrevocable
- lasting
- lost
- noble
- nonreturnable
- nonreversible
- one-way
- permanent
- rooted
- ruined
- set
- settled
- straight
- straightaway
- straightforward
- terminal
- thorough
- unalterable
- unaltered
- unbroken
- unchangeable
- unchanged
- unchanging
- undeviating
- undone
- unidirectional
- uninterrupted
- unmitigable
- unmodifiable
- unremitting
- unsusceptible
- unswerving
- unvarying
