stressful (adj.)

• adverse
• antagonistic
• conflicting
• contrary
• counter
• counteractive
• detrimental
• difficult
• draining
• exhausting
• grueling
• hard
• harmful
• hostile
• inimical
• killing
• miserable
• opposed
• opposing
• opposite
• punishing
• rigorous
• sinister
• straining
• tiresome
• tiring
• toilsome
• troublesome
• troublous
• trying
• unfavorable
• untoward
• wearing
• wearisome
• wearying
• wretched