adverse (adj.)
- adversative
- alien
- antagonistic
- anti
- antipathetic
- antithetic
- antonymous
- balancing
- clashing
- competitive
- conflicting
- contradictory
- contrarious
- contrary
- converse
- counter
- counteractive
- counterpoised
- cross
- deleterious
- detrimental
- difficult
- disadvantageous
- discordant
- discrepant
- dissentient
- fractious
- hard
- harmful
- hostile
- hurtful
- impeding
- inconsistent
- inimical
- injurious
- inverse
- miserable
- negative
- obstinate
- obstructive
- opponent
- opposed
- opposing
- opposite
- oppositive
- perverse
- prejudicial
- recalcitrant
- refractory
- repugnant
- reverse
- rigorous
- sinister
- stressful
- troublesome
- troublous
- trying
- uncooperative
- unfavorable
- unfriendly
- unpropitious
- unsatisfactory
- untoward
- wretched