detrimental (adj.)
- adverse
- antagonistic
- bad
- baleful
- baneful
- conflicting
- contrary
- corrosive
- corrupting
- corruptive
- counter
- counteractive
- counterproductive
- damaging
- deadly
- deleterious
- destructive
- difficult
- disadvantageous
- distressing
- evil
- hard
- harmful
- hostile
- hurtful
- ill
- inimical
- injurious
- lethal
- malefic
- malevolent
- malign
- malignant
- mischievous
- miserable
- negative
- noisome
- noxious
- ominous
- opposed
- opposing
- opposite
- pernicious
- poisonous
- prejudicial
- rigorous
- sinister
- stressful
- toxic
- troublesome
- troublous
- trying
- unfavorable
- unprofitable
- unrewarding
- untoward
- useless
- venomous
- vicious
- virulent
- worthless
- wretched
