operose (adj.)
- abstruse
- arduous
- assiduous
- backbreaking
- brutal
- burdensome
- complex
- critical
- crushing
- delicate
- demanding
- difficult
- diligent
- effortful
- elaborate
- exacting
- forced
- formidable
- grueling
- hairy
- hard
- hard-fought
- heavy
- hefty
- industrious
- intricate
- killing
- knotted
- knotty
- labored
- laborious
- mean
- onerous
- oppressive
- painful
- painstaking
- punishing
- rigorous
- rough
- rugged
- sedulous
- severe
- spiny
- steep
- strained
- strenuous
- thorny
- thorough
- thoroughgoing
- ticklish
- toilsome
- tough
- tricky
- troublesome
- uphill
- wearisome
- wicked