tribulation (n.)

• adversity
• affliction
• aggravation
• annoyance
• blight
• bummer
• calvary
• care
• cross
• crucible
• curse
• difficulty
• downer
• hardship
• irritation
• oppression
• ordeal
• persecution
• plight
• predicament
• pressure
• rigor
• stress
• trial
• trouble
• vicissitude
• visitation