irritation (n.)
- adversity
- affliction
- aggravation
- agitation
- algesia
- amplification
- animation
- annoyance
- arousal
- augmentation
- blight
- bummer
- care
- chafe
- contentiousness
- cross
- curse
- deepening
- deterioration
- difficulty
- disapprobation
- disapproval
- discontent
- displeasure
- dissatisfaction
- downer
- electrification
- embitterment
- enhancement
- enlargement
- exacerbation
- exasperation
- excitation
- excitement
- exhilaration
- festering
- firing
- fomentation
- fret
- gall
- galvanization
- hardship
- incitation
- incitement
- increase
- inflammation
- infuriation
- instigation
- intensification
- irritant
- magnification
- perturbation
- plight
- predicament
- pressure
- provocation
- resentment
- rigor
- sensitiveness
- sore
- soreness
- souring
- stimulation
- stimulus
- stirring
- stress
- tenderness
- trial
- tribulation
- trouble
- vexation
- vicissitude
- worsening
