downer (n.)
- adversity
- affliction
- aggravation
- alcohol
- analgesic
- annoyance
- anodyne
- barb
- barbiturate
- bedevilment
- blight
- blue
- bore
- bother
- botheration
- bummer
- care
- codeine
- cross
- curse
- dejectedness
- dejection
- depressant
- depression
- depressor
- despair
- despondency
- devilment
- difficulty
- discouragement
- disheartenment
- dispiritedness
- dolly
- downheartedness
- drag
- exasperation
- goofball
- harassment
- hardship
- headache
- heartlessness
- heroin
- hop
- hopelessness
- horse
- hypnotic
- irritation
- junk
- laudanum
- liquor
- lotus
- lowness
- malaise
- meperidine
- methadone
- molestation
- morphia
- morphine
- narcotic
- nuisance
- opiate
- opium
- oppression
- pacifier
- paregoric
- persecution
- pessimism
- pest
- phenobarbital
- plight
- predicament
- pressure
- problem
- rainbow
- red
- rigor
- scag
- sedative
- shit
- sleeper
- smack
- soporific
- spiritlessness
- stress
- tar
- tranquilizer
- trial
- tribulation
- trouble
- turps
- vexation
- vicissitude
- worriment
- worry
- yellow
