vicissitude (n.)
- adversity
- affliction
- aggravation
- alteration
- alternation
- annoyance
- asperity
- blight
- bummer
- care
- change
- changeability
- cross
- curse
- difficulty
- diversity
- downer
- fluctuation
- flux
- hardness
- hardship
- inconstancy
- innovation
- irritation
- mischance
- misfortune
- mutability
- mutation
- novelty
- oscillation
- permutation
- plight
- predicament
- pressure
- progression
- reversal
- rigor
- shifting
- shuffling
- sport
- stress
- transposition
- trial
- tribulation
- trouble
- unpredictability
- vacillation
- variability
- variation
- variations
- variety
- wavering
