splenetic (adj.)
- acerb
- acerbic
- acid
- acidic
- acidulent
- acidulous
- acrimonious
- adrenal
- bearish
- bitchy
- bitter
- blase
- burning
- cantankerous
- caustic
- choleric
- churlish
- crabbed
- cranky
- cross
- cross-grained
- crusty
- cussed
- disagreeable
- dispirited
- eccrine
- endocrine
- excitable
- exocrine
- fed-up
- feisty
- fractious
- glandular
- gonadal
- huffish
- huffy
- humoral
- irascible
- irritable
- jaded
- luteal
- mean
- melancholic
- melancholy
- ornery
- ovarian
- pancreatic
- perverse
- prostatic
- rancorous
- resentful
- satiated
- sick
- snappish
- sore
- spiteful
- testy
- thymic
- thyroidal
- tired
- ugly
- virulent
- waspish
- wearied
- weary
- world-weary
