discomfort (n.)
- ache
- angst
- anguish
- anxiety
- bitterness
- bleakness
- boredom
- bother
- burden
- care
- cheerlessness
- depression
- difficulty
- discomposure
- discontent
- dislike
- dismay
- displeasure
- disquiet
- dissatisfaction
- distress
- distressfulness
- dolor
- dread
- dreariness
- dullness
- emptiness
- ennui
- flatness
- grief
- grimness
- hardship
- hurt
- hurting
- inconvenience
- inquietude
- irritation
- joylessness
- lament
- lamentation
- malaise
- misery
- mournfulness
- nausea
- nuisance
- pain
- painfulness
- pathos
- poignancy
- sadness
- savorlessness
- sharpness
- soreness
- sorrow
- sorrowfulness
- spleen
- staleness
- suffering
- tastelessness
- tediousness
- tedium
- trouble
- twinge
- uncomfortableness
- unease
- uneasiness
- unhappiness
- upset
- vexation
- woefulness
- worry